How ViziLite Plus Works

How ViziLite Plus Works

ViziLite Plus with TBlue630 is an oral lesion identification and marking system that is used as an adjunct to the conventional head and neck examination. It is comprised of a chemiluminescent light source (ViziLite) to improve the identification of lesions and a blue phenothiazine dye to mark those lesions identified by ViziLite. ViziLitePlus with TBlue630 is designed to be used in a patient population at increased risk for oral cancer.

ViziLite Oral Lesion Identification System

In clinical trials involving 13,000 female patients, abnormal squamous epithelium in the cervical complex appears acetowhite after rinsing with a dilute acetic acid solution and viewed under chemiluminescent light (Speculite®). Similarly in the oral cavity, after rinsing with a dilute acetic acid solution, abnormal squamous epithelium tissue will appear acetowhite when viewed under ViziLite's diffuse low-energy wavelength light. Normal epithelium will absorb the light and appear dark. ViziLite can assist a dentist or hygienist in identifying an abnormality in the oral cavity.

TBlue630 Oral Lesion Marking System

TBlue630 is a patented, pharmaceutical-grade toluidine blue-based metachromatic dye. It is used to further evaluate and closely monitor changes in ViziLite-identified lesions. It has been proposed that living cells will differentially accumulate toluidine blue based on parameters related to metabolic activity. TBlue630, packaged in an easy to use 3-swab system, provides the deep blue staining that allows ViziLite-identified lesions to be seen clearly under normal light.